Oct 26, 2018. Are there any alternatives to Accutane for treating acne? Yes! Here are some good Accutane brand alternatives, as well as isotretinoin-free. Accutane Generic Generic Accutane Isotretinoin is used primarily in the treatment and prevention of severe nodular cystic acne. Made with vitamin A, Isotretinoin acts to diminish the size and production of oil glands in the face, resulting in clearer, more beautiful skin. 95% of patients who have completed a full cycle of Accutane.