Cipro (generic name: ciprofloxacin) is classified as an antibacterial drug, which is an antibiotic. Antibacterial drugs like Cipro are used to treat bacterial infections. Ciprofloxacin may be used to treat infections in people who have Crohn's disease. Some uncommon but serious side effects from Cipro include difficulty breathing or swallowing, sunburn or blistering, seizures or convulsions, and tendinopathy/tendon rupture. If you experience any of these symptoms call your doctor immediately. Cipro may also cause sensitivity to sunlight (including tanning beds or lamps). Reactions can include sunburn, skin rash, redness, and itching. This includes bone and joint infections, intra abdominal infections, certain type of infectious diarrhea, respiratory tract infections, skin infections, typhoid fever, and urinary tract infections, among others. Ciprofloxacin is used to treat a wide variety of infections, including infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, and chancroid. Ciprofloxacin only treats bacterial infections; it does not treat viral infections such as the common cold. For certain uses including acute sinusitis, lower respiratory tract infections and uncomplicated gonorrhea, ciprofloxacin is not considered a first-line agent. Ciprofloxacin occupies an important role in treatment guidelines issued by major medical societies for the treatment of serious infections, especially those likely to be caused by Gram-negative bacteria, including Pseudomonas aeruginosa. For example, ciprofloxacin in combination with metronidazole is one of several first-line antibiotic regimens recommended by the Infectious Diseases Society of America for the treatment of community-acquired abdominal infections in adults. In other cases, treatment guidelines are more restrictive, recommending in most cases that older, narrower-spectrum drugs be used as first-line therapy for less severe infections to minimize fluoroquinolone-resistance development.
[Posted 12/20/2018]AUDIENCE: Health Professional, Infectious Disease, Cardiology, Patient ISSUE: FDA review found that fluoroquinolone antibiotics can increase the occurrence of rare but serious events of ruptures or tears in the main artery of the body, called the aorta. These tears, called aortic dissections, or ruptures of an aortic aneurysm can lead to dangerous bleeding or even death. They can occur with fluoroquinolones for systemic use given by mouth or through an injection. BACKGROUND: Fluoroquinolone antibiotics are approved to treat certain bacterial infections and have been used for more than 30 years. They work by killing or stopping the growth of bacteria that can cause illness. Without treatment, some infections can spread and lead to serious health problems (see List of Currently Available FDA-Approved Systemic Fluoroquinolones, available at RECOMMENDATION: Healthcare professionals should: Taking ciprofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. Quinolone antibiotics (including ciprofloxacin) may cause serious and possibly permanent tendon damage (such as tendonitis, tendon rupture), nerve problems in the arms and legs (peripheral neuropathy), and nervous system problems. Get medical help right away if you have any of the following symptoms: pain/numbness/burning/tingling/weakness in your arms/hands/legs/feet, changes in how you sense touch/pain/temperature/vibration/body position, severe/lasting headache, vision changes, shaking (tremors), seizures, mental/mood changes (such as agitation, anxiety, confusion, hallucinations, depression, rare thoughts of suicide). Tendon damage may occur during or after treatment with this medication. Stop exercising, rest, and get medical help right away if you develop joint/muscle/tendon pain or swelling. Your risk for tendon problems is greater if you are over 60 years of age, if you are taking corticosteroids (such as prednisone), or if you have a kidney, heart, or lung transplant. This medication may make a certain muscle condition (myasthenia gravis) worse. Tell your doctor right away if you have new or worsening muscle weakness (such as drooping eyelids, unsteady walk) or trouble breathing.
Cipro (ciprofloxacin) is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Ciprofloxacin is used to treat different types of bacterial infections. Cipro is also used to treat people who have been exposed to anthrax or certain types of plague. Fluoroquinolone antibiotics can cause serious or disabling side effects that may not be reversible. Cipro should be used only for infections that cannot be treated with a safer antibiotic. Stop using Cipro and call your doctor at once if you have symptoms such as: headache, hunger, irritability, numbness, tingling, burning pain, confusion, agitation, paranoia, problems with memory or concentration, thoughts of suicide, or sudden pain or movement problems in any of your joints. In rare cases, ciprofloxacin may cause damage to your aorta, which could lead to dangerous bleeding or death. Ciprofloxacin wirkt in wechselndem Ausmaß an der DNA-Topoisomerase Typ II (Gyrase) und der DNA-Topoisomerase Typ IV und verringert dadurch die DNA-Syntheseleistung der Bakterien und die Zellteilung. Darüber hinaus werden auch andere, noch nicht vollends aufgeklärte, Mechanismen diskutiert. Die alte Gruppenbezeichnung "Gyrasehemmer" sollte nicht mehr angewendet werden. Das heisst, der Wirkstoff wirkt umso besser, je schneller die Bakterien sich vermehren. Eine gleichzeitige Blockierung der Proteinbiosynthese oder der RNA-Synthese durch Makrolide, Chloramphenicol oder Rifampicin beeinträchtigt die Wirksamkeit von Ciprofloxacin. Wie andere Fluorchinolone besitzt Ciprofloxacin eine hohe Wirksamkeit gegen gramnegative Erreger, ist aber auch im grampositiven Bereich und bei intrazellulären Erregern aktiv. Die Indikation sind bakterielle Infektionen durch Erreger, die gegenüber Ciprofloxacin empfindlich sind, zum Beispiel: Bei Atemwegsinfektionen sollte Ciprofloxacin mit Vorsicht eingesetzt werden, weil es nicht ausreichend, bzw. kaum gegen die Hauptverursacher Pneumokokken wirkt. Zu den häufigsten Nebenwirkungen zählen Kopfschmerzen, Übelkeit und Durchfall. Im Vergleich zu anderen Antibiotika beobachtet man bei Fluorchinolonen eine höhere Rate an ZNS-Nebenwirkungen.
Coadministration of IV ciprofloxacin and other drugs primarily metabolized by CYP1A2 for example, theophylline, methylxanthines, caffeine, tizanidine, ropinirole, clozapine, olanzapine, and zolpidem results in increased plasma concentrations of co-administered drug and could lead to clinically significant pharmacodynamic adverse reactions of. Die Wirkung des Medikamentes Ciprofloxacin z. B. Ciproxin® wird durch calciumhaltige. Nahrungsmittel oder calciumhaltige Getränke und durch Orangensaft.