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Phentermine is used for a limited period of time to speed weight loss in overweight people who are exercising and eating a low-calorie diet. Phentermine is in a class of medications called anorectics. Phentermine comes as tablets and extended-release capsules. It usually is taken as a single daily dose in the morning or three times a day 30 minutes before meals. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Most people takephentermine for 3 to 6 weeks; the length of treatment depends on how you respond to the medication. Do not take a larger dose, take it more often, or take it for a longer period than your doctor tells you to. If you are taking the extended-release (long-acting) tablets, do not split, chew, or crush them tablet. There are some tablets that can be crushed and mixed with food. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Call your doctor if you have any unusual problems during your treatment with phentermine. Generics and Biosimilars Initiative Journal (Ga BI Journal). DOI: 10.5639/gabij.2012.0103-4.028 Published in: Volume 1 / Year 2012 / Issue 3-4 Category: Review Article Page: 127-131 Author(s): Pieter Dylst, Pharm D, Professor Arnold G Vulto, Pharm D, Ph D, FCP, Professor Steven Simoens, MSc, Ph D Visits: 56049 total, 12 today Introduction: A reference pricing system is a system that establishes a common reimbursement level or reference price for a group of interchangeable medicines, i.e. This article provides an overview of the different characteristics of the different reference pricing systems in Europe. Additionally, the impact of reference pricing on price competition, generic medicine use, pharmaceutical expenditure and health outcome will be discussed. Methods: Studies relevant for this article were found by means of a literature review. A survey was carried out to document the current status of reference pricing systems in Europe. Survey data were collected from member associations of the European Generic medicines Association in the context of their 2011 survey of European drug retail markets. Results: Many European governments have introduced reference pricing systems. Reference pricing systems reduce medicine prices but not always below the reference price, increase the use of medicines priced at or below the reference price, generate savings in pharmaceutical expenditure that tend to be limited to the short term, and do not seem to adversely affect health outcomes.

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