A patient dropped off a prescription for sucralfate at my community pharmacy and commented that she would not have needed this medication if she had been counseled on how to properly take her doxycycline. She took her doses without water and her second dose just before she went to bed; several days into her therapy, her throat began to burn and she experienced pain when swallowing. Pharmacists, as medication experts and the most accessible healthcare professionals, are in the perfect position to prevent such situations. It is, therefore, imperative that pharmacists recognize the medications that are most likely to cause drug-induced esophagitis and know how to counsel patients. The incidence of drug-induced esophagitis is estimated to be 3.9 per 100,000 population per year. The mean age is 41.5 years, with women being affected more often than men; this may be due to the fact that women consume more offending medications. Other risk factors include increasing age, decreased saliva production, and altered esophageal motility. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Pill-induced esophageal injury was first described in 1970. It occurs when a caustic medicinal pill dissolves in the esophagus and releases its noxious content, particularly if transit is delayed. Injury of this type, called is common but unfortunately is under-reported. More than a hundred different medicines have been reported to cause esophageal injury . This injury is a common cause of esophageal complaints such as severe odynophagia, dysphagia, bleeding and even perforation. History and endoscopic examination are very important in diagnosis, and early endoscopic exam in particular may prevent these severe complications .
Sep 8, 2008. Doxycycline-induced esophageal ulcer patients are mostly young. All symptoms of the patient were resolved on the third day of the treatment. Doxycycline-induced esophageal lesions had been examined mostly as mild esophagitis and sometimes as ulceration with a generally benign course. Common reason of this complication has been taking medications just before bedtime, and with a small amount of water 1, 2.