Medrol (methylprednisolone) dose pack (also spelled dosepak) is a corticosteroid used to treat and control inflammation associated with arthritis and other conditions. Medrol is available as 2, 4, 8, 16, 24, and 32-milligram tablets. Medrol is also available as an injectable solution: 20, 40, and 80 milligrams/milliliter. While Medrol can be prescribed at various daily doses or as alternate day therapy, the typical Medrol dose pack is marketed as 4-milligram tablets given over 6 days in decreasing dosages. Directions for the Medrol dose pack are: People who have a known allergy to the components of Medrol should not take the medication. There are many situations in which Medrol should be used with caution, including with active or chronic infection, diabetes mellitus, congestive heart failure, or psychiatric illness. Side effects associated with Medrol are largely dependent on the dose and how often it is taken. Short courses of Medrol, as is the case with the Medrol dose pack, are usually well-tolerated with no or few mild side effects. You should take the Medrol dose pack exactly as prescribed. You should not stop taking the drug suddenly on your own. Day 1: 8 mg PO before breakfast, 4 mg after lunch and after dinner, and 8 mg at bedtime Day 2: 4 mg PO before breakfast, after lunch, and after dinner and 8 mg at bedtime Day 3: 4 mg PO before breakfast, after lunch, after dinner, and at bedtime Day 4: 4 mg PO before breakfast, after lunch, and at bedtime Day 5: 4 mg PO before breakfast and at bedtime Day 6: 4 mg PO before breakfast May be tapered over 12 days (to decrease chance of dermatitis flareup) Methylprednisolone: Usual dosing range, 2-60 mg/day PO divided q6-24hr Methylprednisolone acetate: Usual dosing range, 10-80 mg IM every 1-2 weeks; as temporary substitute for PO, given in daily IM dose equal to daily PO dose; for prolonged effect, given in weekly IM dose equal to 7 times daily PO dose; unlike methylprednisolone sodium succinate, may not be given IV Methylprednisolone sodium succinate: Usual dosing range, 10-250 mg IM/IV up to q4hr PRN Acne Adrenal suppression Amenorrhea Delayed wound healing Delirium Diabetes mellitus Edema Emotional instability Erythema Fluid retention GI perforation Glucose intolerance Growth suppression (children) Hallucinations Headache Hepatomegaly Hepatitis Hypokalemic alkalosis Increased transaminases Insomnia Leukocytosis Menstrual irregularity Myopathy Neuritis Osteoporosis Peptic ulcer Perianal pruritus Pituitary adrenal axis suppression Protein catabolism Pseudotumor cerebri (on withdrawal) Psychosis Sodium and water retention Seizure Tachycardia Ulcerative esophagitis Urticaria Vasculitis Vertigo Weight gain Untreated serious infections Documented hypersensitivity to drug or components (eg, lactose monohydrate from cow milk) Intrathecal administration Systemic fungal infection (except intra-articular injection in localized joint conditions) IM route is contraindicated in idiopathic thrombocytopenic purpura Premature infants (formulations containing benzyl alcohol only) Traumatic brain injury (high doses) Administration of live or live, attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids Use with caution in cirrhosis, ocular herpes simplex, hypertension, diverticulitis, hypothyroidism, myasthenia gravis, peptic ulcer disease, osteoporosis, ulcerative colitis, psychotic tendencies, renal insufficiency, pregnancy, diabetes mellitus, history of seizure disorders, multiple sclerosis, thromboembolic disorders, myocardial infarction Long-term treatment: Risk of osteoporosis, myopathy, delayed wound healing Minimal mineralocorticoid activity Use in septic shock or sepsis syndrome not proven effective and may increase mortality in some patients including patients with elevated serum creatinine and patients who develop secondary infections Clearance of corticosteroids may increase in hyperthyroid patients and decrease in hypothyroid ones; dose adjustments may be necessary Patients receiving corticosteroids should avoid chickenpox or measles-infected persons if unvaccinated Latent tuberculosis may be reactivated (patients with positive tuberculin test should be monitored) Some suggestion (not fully substantiated) of slightly increased cleft palate risk if corticosteroids are used in pregnancy May cause hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing syndrome, or hyperglycemia Prolonged corticosteroid use may result in elevated IOP, glaucoma, or cataracts Killed or inactivated vaccines may be administered; however, the response to such vaccines cannot be predicted Immunization procedures may be undertaken in patients who are receiving corticosteroids as replacement therapy in physiologic doses (eg, for Addison’s disease) Injection may result in dermal and/or subdermal changes forming depressions in the skin at injection site; to minimize incidence of dermal and subdermal atrophy, care must be exercised not to exceed recommended doses in injections; avoid injection into deltoid muscle due to high incidence of subcutaneous atrophy Increased dosage of rapidly acting corticosteroids indicated in patients on corticosteroid therapy subjected to any unusual stress before, during, and after the stressful situation Not for use in the treatment of traumatic brain injury Average and large doses of corticosteroids can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium; dietary salt restriction and potassium supplementation may be necessary; all corticosteroids increase calcium excretion Drug induced secondary adrenocortical insufficiency may be minimized by gradual reduction of dosage; relative insufficiency may persist for months after discontinuation of therapy; therefore, in situation of stress occurring during that period, hormone therapy should be reinstituted Rarely, high doses of cyclically pulsed intravenous methylprednisolone (usually for the treatment of exacerbations of multiple sclerosis at doses of 1 g/day) can induce a toxic form of acute hepatitis; discontinue therapy if it occurs; since recurrence has occurred after re-challenge, avoid use in patients with a history of toxic hepatitis caused by methylprednisolone With increasing doses of corticosteroids, the rate of occurrence of infectious complications increases; corticosteroids may also mask some signs of current infection; corticosteroids may exacerbate systemic fungal infections and should not be used in presence of such infections unless needed to control drug reactions; latent amebiasis or active amebiasis should be ruled out before initiating corticosteroid therapy patients who have spent time in tropics or patients with unexplained diarrhea Lowest possible dose should be used to control condition under treatment; when reduction in dosage possible, reduction should be gradual Risk/benefit decision must be made in each individual case as to dose and duration of treatment and as to whether daily or intermittent therapy should be used Kaposi’s sarcoma reported in patients receiving corticosteroid therapy, most often for chronic conditions; discontinuation of therapy may result in clinical improvement Although controlled clinical trials have shown corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, they do not affect the ultimate outcome or natural history of the disease Psychic derangements may appear when corticosteroids used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank psychotic manifestations; also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids Give consideration to potential for hypersensitivity reactions to cow’s milk ingredients in Solumedrol; if appropriate, stop administration of injection solution Solumedrol and treat patient’s condition accordingly; alternative treatments, including use of corticosteroid formulations that do not contain ingredients produced from cow’s milk, should be considered for acute allergy management Increased incidence of scleroderma reported in patients with systemic sclerosis; use caution Potent glucocorticoid with minimal to no mineralocorticoid activity Modulates carbohydrate, protein, and lipid metabolism and maintenance of fluid and electrolyte homeostasis Controls or prevents inflammation by controlling rate of protein synthesis, suppressing migration of polymorphonuclear leukocytes (PMNs) and fibroblasts, reversing capillary permeability, and stabilizing lysosomes at cellular level Solution: D5/0.5 NS, D5/NS, D5W, LR, NS Additive: Chloramphenicol sodium succinate, cimetidine, clindamycin, dopamine, granisetron, heparin, norepinephrine, penicillin G potassium, ranitidine, theophylline, verapamil Syringe: Diatrizoate meglumine, diatrizoate meglumin/diatrizoate sodium, granisetron, iohexol, iopamidol, iothalamate meglumine, ioxalate meglumine/ioxalate sodium, metoclopramide Y-site (partial list): Acyclovir, amifostine, amiodarone, cisplatin, dopamine, enalaprilat, famotidine, heparin, inamrinone, linezolid, meperidine, metronidazole, midazolam, morphine, sodium bicarbonate Additive: Aminophylline(? ), glycopyrrolate, metaraminol, nafcillin, penicillin G sodium Syringe: Doxapram Y-site: Allopurinol, amsacrine, ciprofloxacin, cisatracurium(? ), etoposide phosphate, fenoldopam, filgrastim, gemcitabine, heparin/hydrocortisone(? ), propofol, sargramostim, vinorelbine, vitamins B and C(? ) Inject directly into vein or into tubing of running IV Injection: Administer over at least 1 minute Infusion: Further dilute reconstituted mixture with D5W, NS, D5/NS, or other compatible solution Push: Administer over 10-20 minutes The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
Methylprednisolone is a corticosteroid medicine that prevents the release of substances in the body that cause inflammation. They cause weight gain by altering the body’s electrolyte and water balances, as well as its metabolism. Generally, the higher the dose of the steroid and the longer you’re on it, the more likely you are to encounter weight gain. Short term corticosteroids are often prescribed to reduce inflammation in the respiratory tract. Short courses of a few days to a couple of weeks don’t usually produce many side effects. For more information please visit: https:// just had this medication for a random flair up with swollen half of face and neck bumps prior. I did feel a bit more water weight but I am a health nut regardless so, I still went to the gym for one hour cardio and 15 minutes arms with a 10 minute sauna. The weight can be water weight from retained fluids (which you will lose quickly as soon as you stop the medicine) but steroids also increase ones appetite so you can gain from increased caloric intake too. Be sure you get a healthy amount of nutritious calories without going over to prevent caloric gain. I also only had one meal daily and snacked on fruit (blueberries and blackberries). Drink a lot of water because it helps flush through the meds and keeps your body working optimally. Be sure you drink plenty of fluids and watch your sodium (salt) intake to prevent water retention. Yes, it sounds crazy but drinking a lot of water prevents water retention! If you have a lot of sodium in the system, it helps to flush it out therefore keeping sodium related retention to a minimum. Hide the potatoe chip bag or have someone else do it for you! Pup I just started the 4mg methylprednisolone 4 mgs for 6 days. I gained 19 lbs in a year but I used for a long time I lost 40 lbs though by exercising in 2012 losed the wheat and sugar and lost the 40 lbs, I just got the 6 days packet will start Saturday but know to stay away from junk so I don't gain not even a lb. I just finished my pack 2 days ago and I'm still munching on everything in site. I hope this ends soon, I'm eating way too much. I still have that flight or fight feeling , uneasy feeling. That depends on many factors your exercise, salt intake and calories. Dexamethasone is used to treat conditions such as arthritis, blood/hormone/immune system disorders, allergic reactions, certain skin and eye conditions, breathing problems, certain bowel disorders, and certain cancers. It is also used as a test for an adrenal gland disorder (Cushing's syndrome). This medication is a corticosteroid hormone (glucocorticoid). It decreases your body's natural defensive response and reduces symptoms such as swelling and allergic-type reactions. Take this medication by mouth as directed by your doctor. Take this medication by mouth with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. If you are using the liquid form of the medication, use a medication-measuring device to carefully measure the prescribed dose. If you take this medication once daily, take it in the morning before 9 AM. If you are taking this medication every other day or on another schedule besides a daily one, it may help to mark your calendar with a reminder.
Your doctor may direct you to take prednisolone 1 to 4 times a day or take a single dose every other day. It may help to mark your calendar with reminders or use. Choisir Solaris Québec Portes et Fenêtres inc. c’est faire confiance à plus de 45 ans de savoir-faire, d’engagement, de qualité et de volonté de révolutionner l’industrie avec des produits qui allient confort, qualité et durabilité.